Proteins synthesized and secreted during rat pancreatic development.

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Proteins synthesized and secreted during rat pancreatic development

The synthesis and secretion of proteins during development of the pancreas was analyzed using two-dimensional gel electrophoresis. The pattern of synthesis of the total proteins of the pancreas was found to change very little from 14 to 18 d gestation. In addition, the protein synthetic pattern of the embryonic pancreas was very similar to the protein patterns of several other embryonic tissues...

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Biochemical analysis of secretory proteins synthesized by normal rat pancreas and by pancreatic acinar tumor cells

We have examined the secretogogue responsiveness and the pattern of secretory proteins produced by a transplantable rat pancreatic acinar cell tumor. Dispersed tumor cells were found to discharge secretory proteins in vitro when incubated with hormones that act on four different classes of receptors: carbamylcholine, caerulein, secretin-vasoactive intestinal peptide, and bombesin. With all horm...

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Biochemical Normal Rat Analysis of Secretory Proteins Synthesized by Pancreas and by Pancreatic Acinar Tumor Cells

We have examined the secretogogue responsiveness and the pattern of secretory proteins produced by a transplantable rat pancreatic acinar cell tumor. Dispersed tumor cells were found to discharge secretory proteins in vitro when incubated with hormones that act on four different classes of receptors: carbamylcholine, caerulein, secretin-vasoactive intestinal peptide, and bombesin. With all horm...

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Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease

Matricellular proteins are secreted, nonstructural proteins that regulate the extracellular matrix (ECM) and interactions between cells through modulation of growth factor signaling, cell adhesion, migration, and proliferation. Despite being well described in the context of nonneuronal tissues, recent studies have revealed that these molecules may also play instrumental roles in central nervous...

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The Serum Proteins of the Rat During Development

INTRODUCTION T H E morphological changes which occur during late embryonic and early postnatal life in common laboratory animals are, with one set of exceptions, now well understood. The exception relates to those changes which require the use of physiological, biophysical, or biochemical techniques. Outstanding among these are the changes in the relative concentrations of the serum proteins (K...

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ژورنال

عنوان ژورنال: Journal of Cell Biology

سال: 1980

ISSN: 0021-9525,1540-8140

DOI: 10.1083/jcb.86.3.784